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Phan TT, Abozguia K, Shivu GN, Mahadevan G, Ahmed I, Williams L, et al

the folate-containing peptidyl fragment Pte-Glu-(AA) n -NH(CHR 2 )C0 2 H (3) is prepared by a polymer-supported sequential approach using standard methods, such as the Fmoc-strategy on an acid- sensitive Fmoc-AA-Wang resin (1), as shown in the following Scheme: Scheme R is Fmoc R 2 is the desired appropriately-protected amino acid side chain DIPEA is TBAF tetrabutylammonium fluoride Appropriately protected amino acid building blocks such as Fmoc-Glu-OiBu, Fmoc-D-Glu-OiBu dressing N 10 -TFA-Pte-OH, and the like, are used, as described in the Scheme, and represented in step (b) by Fmoc-AA-OH

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In rodents, especially mice, the increased DNA content that represents the biochemical effect of hyperplasia may occur by changes in cellular ploidy without actual cytokinesis